Dr. Michael F. Holick, Ph.D., M.D.
Dr. Michael F. Holick

’The D-Lightful Vitamin D for Good Health‘, from I.H.M.C. lecture, published March 16, 2013

Posted by admin on April 1, 2013 under Arthritis, Cancer, Case Files, Diabetes, Infectious Disease, Multiple Sclerosis, Obesity, Osteomalacia, Osteoporosis, Rickets, Vitamin D | Be the First to Comment

View the latest video clip of Dr. Holick speaking about  …’The D-Lightful Vitamin D for Good Health‘, from I.H.M.C. lecture, published March 16, 2013 – click here to view the video clip:   http://www.youtube.com/watch?v=hiGBVDcbFVk&feature=youtu.be

“Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial”

Posted by admin on under Arthritis, Cancer, Case Files, Diabetes, Infectious Disease, Multiple Sclerosis, Obesity, Osteomalacia, Osteoporosis, Rickets, Vitamin D | Be the First to Comment

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells:  A Randomized Double-Blind Clinical Trial” was recently published in PLOS ONE and is available online by clicking here to view:  http://dx.plos.org/10.1371/journal.pone.0058725

Dr. Holick’s Responses to Participant Questions During the December 5, 2008 Live Webinar Presentation “Vitamin D & Chronic Disease Risk”

Posted by mfholick on March 6, 2009 under Cancer, Multiple Sclerosis, Osteomalacia, Osteoporosis, Rickets, Vitamin D | 59 Comments to Read

VITAMIN D AND DISEASE STATES

 

EPILEPSY

 

I have heard that vitamin D may play a role in epilepsy, possibly due to interaction with anti-epileptic drugs.  Is this becoming an acknowledged effect?  And how much vitamin D is necessary to combat the interaction to reduce seizures?

Response:  Epileptic drugs will enhance the destruction of vitamin D making patients who are on anti-seizure medications at higher risk for developing vitamin D deficiency and osteomalacia or rickets.  Measurement of 25-hydroxyvitamin D [25(OH)D] is important in patients on antiepileptic medications.  Often twice as much vitamin D is required to maintain a blood level of  25(OH)D of > 30 ng/ml.  Thus, 2,000-4,000 IU of vitamin D/d is usually needed.  An alternative is to take 50,000 IU of vitamin D2 either once every week or once every two weeks depending on the serum 25-hydroxyvitamin D level.

 

MENTAL HEALTH

 

What is your position on vitamin D and depression and schizophrenia?

Response:  There is evidence that vitamin D deficiency during pregnancy increases the risk of the child developing schizophrenia during their adult life.  There is also evidence that vitamin D receptors exist in the brain, and that the active form of vitamin D, 1,25-dihydroxyvitamin D, Read more of this article »

Osteoporosis and Vitamin D

Posted by admin on November 27, 2008 under Osteoporosis, Vitamin D | 5 Comments to Read

Vitamin D deficiency will cause removal of both the calcium and matrix from the bone, and as a result, will cause osteopenia and can precipitate and exacerbate osteoporosis.  Unlike osteomalacia which causes bone pain, osteoporosis, which is porotic bone, i.e., holes in the bones and loss of bone does not cause bone pain unless there is an acute fracture.  Typically this pain resolves as the fracture heals and can be easily distinguished from osteomalacia.  

References:

Bischoff-Ferrari, HA, Giovannucci, E., Willett, W.C., Dietrich, T., and Dawson-Hughes, B.  Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.  Am J Clin Nutr  2006; 84:18-28.  

Boonen S, Bischoff-Ferrari A, Cooper C, Lips P, Ljunggren O, Meunier PJ, Reginster JY.  Addressing the musculoskeletal components of fracture risk with calcium and vitamin D:  a review of the evidence.  Calcif Tissue Int  2006; 78(5):257-70.

Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ.  Vitamin D3 and calcium to prevent hip fractures in elderly women.  N Engl J Med 1992; 327(23):1637-1642.