Dr. Michael F. Holick, Ph.D., M.D.
Dr. Michael F. Holick

Infectious Diseases and Vitamin D

Posted by admin on November 27, 2008 under Infectious Disease, Vitamin D | 4 Comments to Read

It has long been recognized that patients with tuberculous do better when treated with vitamin D or exposed to sunlight.  It was recently recognized that the immune cell known as the macrophage needs vitamin D in order to produce a peptide which is responsible for killing infectious agents such as tuberculous.  It has been speculated that one of the reasons that influenza occurs in the winter time in tepid climates is because the sun is unable to produce vitamin D, and the resulting vitamin D insufficiency may promote and enhance the infectivity of the influenza virus.  

References:
Adams,J.S., Gacad,M.A., Anders,A., Endres,D.B., and Sharma,O.P. 1986. Biochemical indicators of disordered vitamin D and calcium homeostasis in sarcoidosis. Sarcoidosis 3:1-6.

Gallo, R.L., Eisenberg, D., Hewison, M., Hollis, B.W., Adams, J.S., Bloom, B.R., Modlin, R.L.  2006.  Toll-like receptor Triggering of a vitamin D-mediated human antimicrobial response.  Sciencexpress.  3:1770-1773.  
Liu, P.T., Stenger, S., Li, H., Wenzel, L., Tan, B.H., Krutzik, S., Ochoa, M.T., Schauber, J., Wu, K., Meinken, C., Kamen, D.L., Wagner, M., Bals, R., Steinmeyer, A., Zugel, U.