Dr. Michael F. Holick, Ph.D., M.D.
Dr. Michael F. Holick

Dr. Holick’s Responses to Participant Questions During the December 5, 2008 Live Webinar Presentation “Vitamin D & Chronic Disease Risk”

Posted by mfholick on March 6, 2009 under Cancer, Multiple Sclerosis, Osteomalacia, Osteoporosis, Rickets, Vitamin D | 59 Comments to Read

VITAMIN D AND DISEASE STATES

 

EPILEPSY

 

I have heard that vitamin D may play a role in epilepsy, possibly due to interaction with anti-epileptic drugs.  Is this becoming an acknowledged effect?  And how much vitamin D is necessary to combat the interaction to reduce seizures?

Response:  Epileptic drugs will enhance the destruction of vitamin D making patients who are on anti-seizure medications at higher risk for developing vitamin D deficiency and osteomalacia or rickets.  Measurement of 25-hydroxyvitamin D [25(OH)D] is important in patients on antiepileptic medications.  Often twice as much vitamin D is required to maintain a blood level of  25(OH)D of > 30 ng/ml.  Thus, 2,000-4,000 IU of vitamin D/d is usually needed.  An alternative is to take 50,000 IU of vitamin D2 either once every week or once every two weeks depending on the serum 25-hydroxyvitamin D level.

 

MENTAL HEALTH

 

What is your position on vitamin D and depression and schizophrenia?

Response:  There is evidence that vitamin D deficiency during pregnancy increases the risk of the child developing schizophrenia during their adult life.  There is also evidence that vitamin D receptors exist in the brain, and that the active form of vitamin D, 1,25-dihydroxyvitamin D, Read more of this article »

Osteomalacia and Vitamin D

Posted by admin on November 27, 2008 under Osteomalacia, Vitamin D | 3 Comments to Read

Vitamin D deficiency causes a defect in the ability of the body to deposit calcium into the collagen jello-like matrix in the bone.  As a result, the covering on the bone which contains pain sensing nerves is easily deformed resulting in throbbing aching bone pain.  Patients with osteomalacia often complain of achiness in their muscles and bones.  These non-specific aches and pains in the bones and muscles are often misdiagnoses as fibromyalgia or chronic fatigue syndrome.  There have been several studies demonstrating that patients with severe bone and muscle pain and muscle weakness associated with osteomalacia have dramatic improvement in their symptoms when vitamin D deficiency is corrected.  It takes months to years to develop osteomalacia and associated symptoms and it takes three to six months before significant improvement in symptoms results from correcting vitamin D deficiency.  

References:

Holick, M.F.  Vitamin D deficiency:  What a Pain it is.  Mayo Clin. Proc.  2003; 78(12): 1457-1459.

Malabanan AO, Turner AK, Holick MF. Severe generalized bone pain and osteoporosis in a premenopausal black female: effect of vitamin D replacement. J Clin Densitometr . 1998;1:201-204.